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by Menon, D.V. et al.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8586, USA

Our data suggest that chlorthalidone, the first-line drug therapy for hypertension, causes persistent activation of sympathetic nervous system and insulin resistance in hypertensive patients.
J. Clin. Endocrinol. Metab. 2009; 4:1361-6

[See paper]

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